Pregnancy: Immunosuppression

Some immunosuppressive drugs are known to cause a structural or functional change in the foetus, known as teratogenic drugs, and so this is a critical area of concern in transplant medicine, and discussion with a patient’s transplant team is important to ensure the most appropriate immunosuppressive regime is provided for the best care of both parent and embryo.

NHS England Specialised Commissioning has not undertaken a specific impact assessment of taking immunosuppressant drugs during pregnancy on babies in utero, specifically in the context of transplant recipients. However, guidance is typically informed by a combination of clinical experience, research literature, and recommendations from broader medical bodies. The policies and practices in place in solid organ transplant centres are evidence based, and consider the safety and efficacy of the use of these drugs, including where National Institute for Health and Care Excellence evaluations have taken place.