Pancreatic Enzyme Replacement Therapy

There are ongoing supply issues with pancrelipase, also known by the brand name Creon, capsules, used by patients with conditions such as cystic fibrosis and certain cancers including pancreatic and neuroendocrine cancer. The Department is continuing to work with the suppliers of Creon and other licensed alternatives to help resolve the supply issues in the short and longer term. Through these discussions supply quantities have improved this year, and we are in regular communication with suppliers on expected volumes for 2026.The Department has also reached out to specialist importers who have sourced unlicensed stock to assist in covering the remaining gap in the market. We have widely disseminated comprehensive guidance to healthcare professionals, including National Health Service trusts, general practices, and pharmacies, about these supply issues, which provide advice on how to manage patients whilst there is disruption to supply. The Department will continue to work closely with the suppliers to resolve the issues as soon as possible, to ensure patients have continuous access to medicines.