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Puberty Suppressing Hormones

Asked by Sarah PochinReform UKDepartment of Health and Social CareTabled Answered 19 December 2025UIN 97475

The question

To ask the Secretary of State for Health and Social Care, what assessment the Department has made of the potential impact of puberty suppression on levels of likelihood of progression to cross sex hormones.

Answered by Karin Smyth

The Cass Review recommended that there is a need to build a more robust evidence base for the use of puberty suppressing hormones as a response to gender dysphoria in childhood, through a carefully considered research programme. The PATHWAYS Trial Study has been established for that purpose, in which puberty suppression will be offered solely within the context of the comprehensive assessment and psychosocial support now offered by the National Health Service.

Kings College London University, which is leading the research, has advised that it is not possible to know before starting puberty suppressing hormones what the treatment plan for any single young person will be at the end of the trial. This will depend on several factors, including their experience of puberty suppressing hormones, their mental and physical health, and their preferences for future care.

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