Genomics
The question
To ask the Secretary of State for Health and Social Care, what assessment he has made of the implications for his policies of the evidence base that underpins the use of tissue stabilisers - as an alternative to fresh frozen tissue - for whole genome sequencing.
Answered by Preet Kaur Gill
NHS England has produced national sample handling guidance, including for whole genome sequencing (WGS), of solid tumours to standardise the collection, processing, and transport of tumour samples, helping to maintain DNA quality and support access to precision diagnostics. As part of the guidance, approaches to the handling of fresh tissue have been reviewed, including the use of tissue stabilisers as an alternative to fresh frozen tissue.
The Department has not undertaken a specific, separate assessment of whether reliance on tissue stabilisers could limit access to precision diagnostics, WGS, clinical trials, or research. However, the guidance indicates that the use of tissue stabilisers is intended to support, rather than limit, access to genomic testing, including WGS, by enabling more consistent sample handling pathways across the National Health Service. The aim is to reduce some of the barriers of having to acquire, freeze, and transport the frozen tissue, helping to speed up processes and improve consistency.
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